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pollutants, as nutrition can have a buffering or synergistic effect on PM-induced cardiovascular responses and effects on the fetus. 5.5 Conclusions There is clear evidence that, with a few exceptions, poorer people tend to live in lower-quality environments and are more exposed to air pollution. This inequality is not necessarily an injustice, provided that the levels of exposure are not hazardous and that deprivation does not increase vulnerability; however, neither of these conditions seems to apply. While many aspects of air quality have improved over the past few decades, there are still breaches of air quality standards, particularly in urban areas, and some important air pollutants are 'non-threshold toxins', meaning that any level of exposure will have an impact at a population level. Deprivation seems particularly linked with increasing susceptibility to PM exposure and cardiorespiratory effects, although the precise mechanisms remain unclear. There is a general pattern that deprived populations, although not always more exposed, experience greater harmful effects of air pollution because of vulnerability factors. There is also some research suggesting that obesity may negatively modify risk and that exposure to some chemicals may be implicated in the development of metabolic syndrome. It is also clear that poorer people have other health, social and environmental stressors, such as poor-quality housing, higher 0 100 England and Wales Routine Semi-routine Lower supervisory and technical Small employers, own account workers Intermediate Lower managerial, professional Higher managerial, professional E SW SE EM Region Mortality rate per 100,000 WM YH L NW NE 200 300 400 500 600 700 800 Fig 18. Age-standardised mortality rates by socio-economic classification and region, for men aged 25–64 years, 2001–2003. 14 Data originally from Office for National Statistics (2008): ww.ons.gov.uk/ons/rel/hsq/ health-statistics-quarterly/no—40—winter-2008/regional-differences-in-male-mortality-inequalities-using- the-national-statistics-socio-economic-classification—england-and-wales—2001-03.pdf. © Royal College of Physicians 2016 75 5 Our vulnerable groups

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